Early Life Stress, FKBP5 Polymorphisms, and Quantitative Glycemic Traits
نویسندگان
چکیده
منابع مشابه
Associations Between Self-Reported and Objectively Recorded Early Life Stress, FKBP5 Polymorphisms, and Depressive Symptoms in Midlife
BACKGROUND FK506-binding protein 51 is involved in hypothalamic-pituitary-adrenal axis regulation. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene have been shown to interact with retrospectively self-reported early life stress (ELS) in patients with psychiatric disorders. We examined interactions between three selected FKBP5 SNPs and self-reported and objectively recorded ELS in relat...
متن کاملAssociation of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
CONTEXT In addition to trauma exposure, other factors contribute to risk for development of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors are contributory, with child abuse providing significant risk liability. OBJECTIVE To increase understanding of genetic and environmental risk factors as well as their interaction in the development of PTSD by gen...
متن کاملUnderstanding personality traits from early life experiences.
The contribution of early experiences towards the onset of personality disorder has often been stressed. However, the contribution to trait personality has received less attention. To examine the impact of early experiences on the development of personality, two subscale scores of the Eysenck Personality Questionnaire (EPQ): neuroticism (N) and extroversion (E), were used to assess a total of 2...
متن کاملQuantitative Genetics and Quantitative Traits
Introduction In the chapter on Mendel and Morgan, we saw how the transmission of genes from one generation to another follows precise mathematical formula. The traits discussed in that chapter, however, were discrete traits—peas are either yellow or green, someone either has a disorder or does not have the disorder. But many behavioral traits are not like these clear-cut, have-it-or-don’t-have-...
متن کاملEarly Life Stress, Mood, and Anxiety Disorders
Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders including major depression, posttraumatic stress disorder, and bipolar disorder. The Diagnostic and Statistics Manuel of Mental Disorders (DSM) diagnostic cate...
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ژورنال
عنوان ژورنال: Psychosomatic Medicine
سال: 2017
ISSN: 1534-7796,0033-3174
DOI: 10.1097/psy.0000000000000439